Canis ISSN: 2398-2942

Thyrotropin releasing hormone

Introduction

Name

  • Thyrotropin releasing hormone (TRH).

Class of drug

  • Hormone.

Description

Storage requirements

  • Keep refrigerated.

Uses

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Indications

  • Assessment of thyroid function:
    • To aid diagnosis of hypothyroidism Hypothyroidism in dogs.
    • As an aid to diagnosis of hyperthyroidism in cats.
  • Assessment of TSH reserve.
  • Has been somewhat superceded by the use of TSH assay Thyroid stimulating hormone assay in the diagnosis of canine hypothyroidism.

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs



Decrease serum T4
  • Anabolic and adrenogenic steroids, antithyroid agents (carbimazole, PTU), barbiturates, corticosteroids (?), diazepam, heparin, mitotane (OP-DDD), nitroprusside, phenylbutazone, phenytoin and salicylates.
Increase serum T4
  • Fluorouracil, insulin, estrogens, propanolol and prostaglandins F2 alpha (Dinoprost).

Adverse Reactions

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Further Reading

Publications

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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