Canis ISSN: 2398-2942

Tetracycline

Introduction

Name

  • Tetracycline.

Class of drug

  • Tetracycline antibiotic.

Uses

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Indications

  • A bacteriostatic antibiotic which inhibits the growth of many gram-positive and gram-negative bacteria, several rickettsiae, mycoplasma Mycoplasmas and ureaplasmas , spirochaetes Borrelia burgdorferi (Lyme disease Arthritis: borrelial ) and other microbes.
  • Tetracycline differs from oxytetracycline Oxytetracycline in its lipid solubility (oxytetracycline low solubility, tetracycline intermediate solubility) although this is unlikely to be of clinical relevance.
  • Ophthalmic tetracycline is the preferred agent for the treatment of chlamydia, mycoplasma or rickettsial eye infections.
  • Tetracycline is also used to cause pleurodesis.

Administration

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Pharmocokinetics

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Precautions

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Interactions

with other drugs



Penicillins
  • The bactericidal action of the penicillins may be inhibited by bacteriostatic antibiotics.
Drugs inhibiting absorption of orally administered tetracyclines
  • Antacids containing divalent or trivalent cations (magnesium, calcium, aluminium).
  • Iron Iron.
  • Oral sodium bicarbonate Sodium bicarbonate.
Digoxin
  • The bioavailability of digoxin Digoxin may be increased by tetracyclines for months after their discontinuation. This may lead to digoxin toxicity.
Anticoagulants
  • Plasma prothrombin activity may be decreased by tetracyclines and therefore patients on anticoagulant therapy may need a dose adjustment.
Methoxyflurane
  • Tetracyclines may increase the nephrotoxic effects of methoxyflurane Methoxyflurane.
Theophyllines
  • The gastrointestinal (GI) effects of tetracyclines may be increased.

with diagnostic tests

  • Plasma prothrombin activity may be decreased.

Adverse Reactions

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Further Reading

Publications

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham:BSAVA.

ADDED