Canis ISSN: 2398-2942

Terbinafine

Contributor(s): Rosanna Marsella, Sue Paterson

Introduction

Class of drug

  • Allylamine antifungal agent.

Uses

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Indications

  • Treatment of dermatophytosis Skin: dermatophytosis in dogs where systemic therapy is needed and licensed drugs are not suitable.
  • Malassezia dermatitis/otitis Skin: malassezia disease.
  • Subcutaneous and systemic fungal infections in dogs.

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

  • Fewer potential drug interactions than ketoconazole Ketoconazole as does not inhibit cytochrome P450 system.

Rifampicin

  • Plasma concentrations of terbinafine decreased.

Cimetidine

  • Plasma concentrations of terbinafine increased.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from VetMed Resource and PubMed.
  • Forster S L et al (2018) A randomized placebo-controlled trial of the effiacy and safety of a terbinafine, florfenicol and betamethasone topical ear formulation in dogs for the treatment of bacterial and/or fungal otitis. BMC Vet Res 14(1), 1-11 PubMed.
  • King S B et al (2018) A randomized, controlled, single-blinded multi-centre evaluation of the effiacy and safety of a once weekly two dose otic gel containing florfenicol, terbinafine and betamethasone administered for the treatment of canine otitis externa. BMC Vet Res 14(1), 1-9 PubMed.
  • Moriello K A, Coyner K, Paterson S, Mignon B (2017) Diagnosis and treatment of dermatophytosis in dogs and cats: Clinical Consensus Guidelines of the World Association for Veterinary Dermatology. Vet Dermatol 28(3), 266-e68 PubMed.

Other sources of information

  • BSAVA Small Animal Formulary. Ramsey I (Editor in chief) (2014) 8th edn. Cheltenham: BSAVA.

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