Canis ISSN: 2398-2942

Suxamethonium

Synonym(s): Succinycholine

Contributor(s): John Dodam

Introduction

Name

  • Suxamethonium.

Class of drug

Uses

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Indications

  • Few, if any, indications for use in the dog.
  • Used to facilitate endotracheal intubation in cats and primates.

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs


Do not use if had organophosphorous (OP) flea treatment in last month as this can prolong action of suxamethonium for days to weeks

Drugs enhancing action of suxamethonium
Neostigmine and pyridostigmine
  • Should not be administered with suxamethonium as they inhibit pseudocholinesterases, thereby enhancing effect of suxamethonium.
Diazepam
  • May reduce the duration of action of suxamethonium.
Digoxin
  • Suxamethonium may cause a sudden outflux of potassium from muscle cells, which may initiate arrhythmias. This also happens in animals with denervation type diseases.
    Anticholinesterase drugs aggravate blockade and prolong action

Adverse Reactions

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Further Reading

Publications

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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