Canis ISSN: 2398-2942

Sulfasalazine

Introduction

Name

• Sulfasalazine.

Class of drug

• Sulfonamide/Salicylate.

Description

Molecular formula

• 5-aminosalicylic acid (5-ASA) and sulfapyridine connected by an azo bond.

Uses

Indications

• Chronic colitis Colitis: overview.

Administration

Pharmacokinetics

Precautions

Interactions

with other drugs

Digoxin

• Absorption may be decreased by sulfasalazine.

Folic acid

• Absorption may be decreased by sulfasalazine.

Drugs whose action may be enhanced

• Sulfonamides may displace highly protein bound acidic drugs such as:
• • Glipizide Glipizide and other oral hypoglycemics.
  • Methotrexate Methotrexate.
  • Phenylbutazone Phenylbutazone.
  • Phenytoin Phenytoin.
  • Salicylates Acetyl salicylic acid.
  • Thiazide diuretics.
  • Warfarin Warfarin.

Adverse Reactions