ISSN 2398-2942      

Sotalol

icanis

Introduction

Name

  • Sotalol.

Class of drug

  • Anti-arrhythmic (non-selective ß-adrenergic blocking drug with potassium channel blocking effects - classified as type III anti-arrhythmic under the Vaughan Williams classification).

Description

Chemical name

  • Sotalol HCL (racemic mixture ofd-andl-stereo-isomers).

Physical properties

  • White crystalline solid.
  • Soluble in water.

Storage requirements

  • Store at room temperature.

Uses

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Indications

  • Used for the treatment of ventricular tachycardias Ventricular tachycardia in dogs.
  • Treatment of Boxers Boxer with severe ventricular tachycardias and syncope.
  • Other indications may include the management of supraventricular tachycardias including atrioventricular nodal independent supraventricular tachycardia and atrioventricular reciprocating tachycardia associated with atrioventricular accessory pathways.
  • Atrial fibrillation Heart: atrial fibrillation and atrial flutter.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMed Resource.
  • Meurs K M et al (2002) Comparison of the effects of four antiarrhythmic treatments for familial ventricular arrhythmias in Boxers. J Am Vet Med Assoc 221(4),522 - 527 PubMed.
  • Wright K N (2000) Assessment and Treatment of Supraventricular tachyarrhythmias. Kirk's Current Veterinary Therapy XIII - Sm Anim Pract.726 - 730.
  • Atkins C E & Wright K N (1995) Supraventricular tachycardia associated with accessory atrioventricular pathways in dogs. Kirk's Current Veterinary Therapy XII - Sm Anim Pract 807 - 813.

Other sources of information

  • Moise S N (2002) Chronic management of tachyarrhythmias in the dog. Proceedings from the 26th Annual Waltham Symposium.
  • Plumb D C (2002) Veterinary Drug Handbook, Fourth Edition. Pharma Vet Publishing, Minnesota.
  • Braunwald E, Zipes D P& Libby P (2001) Heart Disease: A Textbook of Cardiovascular Medicine. 6th Edn. W B Saunders Co, Philadelphia.
  • Fox P R, Sisson D & Moise N S (1999)Textbook of Canine and Feline Cardiology: principles and clinical practice. 2nd edn.W B Saunders Co, Pennsylvania.
  • Kittleson M D & Kienle R D (1998)Small Animal Cardiovascular Medicine.Mosby, St Louis.
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