Canis ISSN: 2398-2942

Sevoflurane

Synonym(s): Sevo

Contributor(s): John Dodam, Sheilah Robertson

Introduction

Name

  • Sevoflurane.

Class of drug

  • Halogenated inhalation anesthetic drug.

Description

Chemical name

  • Fluoromethyl 2,2,2-trifluoro-l-(trifluoromethyl)ethyl ether.

Molecular formula

  • CH2F.O.CH(CF3).CF3

Molecular weight

  • 200.

Physical properties

  • Clear, colorless non-pungent volatile liquid (isopropyl ether).
  • Boiling point 58.5 degrees C, saturated vapor.
  • Blood-gas partition coefficient of 0.7.
  • Pressure at 20 degrees C of 160 mmHg.

Storage requirements

  • Store in manufacturers' amber colored bottles.
  • Store at room temperature (1530 degrees C).

Uses

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Indications

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

  • Prolongs the effects of neuromuscular blocking agents.
  • Interacts with desiccated carbon dioxide (soda lime and barium hydroxide lime) absorbents to produce carbon monoxide and Compound A.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • K R Bransonet al(2001)A multisite case report on the clinical use of sevoflurane in dogs.J Am Anim Hosp Assoc37(5), 420-432.
  • Clarke K W (1999)Desflurane and sevolfurane, New volatile anesthetic agents.Vet Clin North Am Small Anim Pract29(3), 793-810.
  • Johnson RA, Striler E, Sawyer D Cet al(1998)Comparison of isoflurane with sevoflurane for anesthesia induction and recovery in adult dogs.Am J Vet Res59,478-481.
  • Mutoh T, Nishimura R, Kim H Yet al(1997)Cardiopulmonary effects of sevoflurane, compared with halothane, enflurane, and isoflurane, in dogs.Am J Vet Res58,885-890.


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