Canis ISSN: 2398-2942

Selegiline hydrochloride

Introduction

Name

  • Selegiline.

Class of drug

  • Alpha-2-agonist.

Uses

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Indications

  • Treatment of Canine Cognitive Dysfunction (Cognitive Dysfunction Syndrome) Canine cognitive dysfunction syndrome (CDS).
  • Treatment of behavioral disorders of emotional origin, such as depression and anxiety.
  • In association with behavioral therapy for treatment of signs of emotional origin observed in behavioral conditions eg overactivity, separation anxiety, phobias and unsociable behavior Lack / loss of or inadequate housetraining.
  • Unlicensed use in the cat as MAOB inhibitor and behavior modifier.
  • In USA licensed for use in treatment of uncomplicated pituitary-dependent hyperadrenocorticism Hyperadrenocorticism (up to 50% cases may fail to respond).

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

  • Discontinue at least for 24 hours before and after the use of other alpha-2-agonists for anesthesia or sedation.
  • Avoid tetracyclic antidepressants.
  • Avoid use with ephedrine or potential MAO inhibitors (eg amitraz Amitraz ) or phenothiazines.
  • Should not be administered with pethidine Pethidine , fluoxetine Fluoxetine hydrochloride or tricyclic antidepressants, eg amitryptiline Amitryptiline , doxepin Doxepin , chlomipramine.
  • The effect of morphine Morphine is potentiated when used simultaneously.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Reusch C E, Steffen T & Hoerauf A (1999)The efficacy of L-Deprenyl in dogs with PDH.JVIM13, 291-301.
  • Peterson M E (1999)Medical treatment of PDH in dogs - should L-Deprenyl ever be used?JVIM13, 289-291.

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