Canis ISSN: 2398-2942

Sarolaner

Synonym(s): Simparica™

Contributor(s): Lindsay Starkey

Introduction

Name

  • Sarolaner (Simparica™).

Class of drug

  • Systemic acaricide and insecticide belonging to the isoxazoline group.

Description

Chemical name

  • 1-(5’-((5S)-5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3’-H-spiro(azetidine-3,1’-(2)benzofuran)-1-yl)-2-(methylsulfonyl)ethanone.

Molecular formula

  • C23H18Cl2F4N2O5S

Molecular weight

  • 625.9

Physical properties

  • Chewable tablets (liver flavored).

Storage requirements

  • Store at or below 30°C (86°F) with excursions permitted up to 40°C (104°F).
  • Keep out of the sight and reach of children.

Uses

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Indications

Please note differences between US and UK/EU labels.

Administration

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Pharmocokinetics

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Precautions

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Interactions

With other drugs

  • None known.
  • Has been used safely in dogs treated with commonly prescribed vaccines, parasiticides and other medications.

Adverse Reactions

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Further Reading

Publications

Refereed Papers

  • Recent references from VetMed Resource and PubMed.
  • Rugg D, Little S & Breitschwerdt E (2016) Special issue: Sarolaner - a novel ectoparasiticide for dogs. Vet Parasitol 222, 1-72.
  • Geurden T, Becskei C, Grace S, Strube C, Doherty P, Liebenberg J, Mahabir SP, Slootmans N, Lloyd A, Six RH (2016) Efficacy of a novel oral formulation of sarolaner (Simparica™) against four common tick species infesting dogs in Europe. Vet Parasitol 222, 33-36 PubMed
  • Becskei C, De Bock F, Illambas J, Mahabir SP, Farkas R, Six RH (2016) Efficacy and safety of a novel oral isoxazoline, sarolaner (Simparica™) in the treatment of naturally occurring flea and tick infestations in dogs presented as veterinary patients in Europe. Vet Parasitol 222, 49-55 PubMed
  • Cherni JA, Malabir SP, Six RH (2016) Efficacy and safety of sarolaner (Simparica™) against fleas on dogs presented as veterinary patients in the United States. Vet Parasitol  222, 43-48 PubMed.  
  • Six RH, Becskei C, Carter L, Gale B, Young DR, Mahabir SP, Chapin S, Myers MR (2016) Evaluation of the speed of kill, effects on reproduction, and effectiveness in a simulated infested-home environment of sarolaner (Simparica™) against fleas on dogs. Vet Parasitol 222, 23-27 PubMed.
  • Six RH, Geurden T, Carter L, Everett WR, McLoughlin A, Mahabir SP, Myers MR, Slootmans N (2016) Evaluation of the speed of kill of sarolaner (Simparica™) against induced infestations of three species of ticks (Amblyomma maculatum, Ixodes scapularis, Ixodes ricinus) on dogs. Vet Parasitol 222, 37-42 PubMed.
  • Six RH, Becskei C, Mazaleski MM, Fourie JJ, Mahabir SP, Myers MR, Slootmans N (2016) Efficacy of sarolaner, a novel oral isoxazoline, against two common mite infestations in dogs: Demodex spp. and Otodectes cynotis. Vet Parasitol 222, 62-66 PubMed.
  • Becskei C, De Bock F, Illambas J, Cherni JA, Fourie JJ, Lane M, Mahabir SP, Six RH (2016) Efficacy and safety of a novel oral isoxazoline, sarolaner (Simparica™), for the treatment of sarcoptic mange in dogs. Vet Parasitol 222, 56-61 PubMed.

Other sources of information


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