Canis ISSN: 2398-2942

Salbutamol sulfate

Synonym(s): Albuterol sulfate

Contributor(s): Elizabeth Rozanski, Vetstream Ltd

Introduction

Name

  • Salbutamol sulfate (International).
  • Albuterol sulfate (USAN).

Class of drug

  • ß-2-adrenergic agonist.

Description

Chemical name

  • alpha1-[(tert-butylamino)methyl]-4-hydroxy-m-xylene-alpha, alpha'-diol sulfate.

Molecular formula

  • (CH13 H21 NO3 )2.H2SO4.

Molecular weight

  • 576.70.

Physical properties

  • Microcrystalline inhaled suspension.
  • Pressurized aluminium canister with a metered valve supplied with a plastic actuator (inhaler).
  • Available as a oral tablet as well as liquid for nebulization.

Storage requirements

  • Store at room temperature.
  • Do not expose to excessive heat.
  • Do not pierce the canister, even when empty.

Uses

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Indications

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

  • Increase risk of heart/respiratory problems if used with other sympathomimetic drugs like phenylephrine Phenylephrine or ephedrine.
  • May have decreased effect if used with propranolol Propranolol and other beta blockers.
  • May have increased effect if used with tricyclic antidepressants or monoamine oxidase inhibitors (MAOIs).
  • Digoxin Digoxin concentrations may be reduced if used concurrently.
  • May increase risk of abnormal heart rhythms if used with gaseous anesthetics.
  • Will decrease potassium concentrations.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from VetMedResource and PubMed.
  • Padrid P (2006) Use of inhaled medications to treat respiratory diseases in dogs and cats. J Am Anim Hosp Assoc 42(2) 165-169PubMed.

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