Canis ISSN: 2398-2942

S-adenosylmethionine

Synonym(s): SAM-e, SAMe, S-adenosyl-methionine, ademetione

Contributor(s): David C Twedt

Introduction

Name

  • S-adenosylmethionine.

Class of drug

  • Nutraceutical.
  • Nutritional supplement.

Description

Chemical name

  • S-Adenosyl-L-Methionine.

Molecular formula

  • C15H22N6O5S.

Molecular weight

  • 399.145 g/mol.

Physical properties

  • Solid.

Storage requirements

  • Store in a cool, dry place.
  • Enteric-coated tablets:
    • Keep tablets in original blister pack until used.
    • These tablets should not be split or crumbled.
  • Chewable tablets:
    • Keep bottle lid tightly closed to ensure freshness.

Uses

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Indications

  • Management of hepatic and hepatobiliary disease.
  • Support of brain health including management of cognitive dysfunction.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Rème CA, Dramard V et al(2008) Effect of S-adenosylmethionine tablets on the reduction of age-related mental decline in dogs: a double-blinded, placebo-controlled trial. Vet Ther 9(2), 69-82PubMed.
  • Center S A, Warner K L, McCabe J et al(2005) Evaluation of the influence of S-adenosylmethionine on systemic and hepatic effects of prednisolone in dogs. Am J Vet Res 66(2), 330-341PubMed.
  • Center S A, Randolph J F, Warner K L et al (2005) The effects of S-adenosylmethionine on clinical pathology and redox potential in the red blood cell, liver, and bile of clinically normal cats. J Vet Intern Med 19, 303-314.
  • Webster C R L, Boria P, Usechak P, Anwer M S (2002) S-adenosylmethionine and cAMP confer differential cytoprotection against bile acid-induced apoptosis in canine renal tubular cells and primary rat hepatocytes. Vet Ther 3(4), 474-484 PubMed.

Other sources of information

  • Plumb D C (2011) S-adenosyl-methionine. In: Plumb's Veterinary Drug Handbook 7th ed. Wiley-Blackwell, Ames, IA, pp 909-911.
  • Griffin D W, Whalen M O, Filburn C R (2009) Bioavailability of a novel formulation of S-adenosylmethionine in beagle dogs. J Vet Intern Med 22(3), 767 (abstract #284).
  • Center S A, Warner K L (2002) Pharmacokinetics of S-adenosylmethionine delivered in enteric coated tablets to healthy cats: acute and chronic oral dosing study. Proceedings of the 27th World Small Animal Veterinary Association Congress.

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