Canis ISSN: 2398-2942

Robenacoxib

Synonym(s): Onsior®

Contributor(s): Jo Murrell

Introduction

Name

  • Robenacoxib.

Class of drug

  • COX-2 selective NSAID (non-steroidal anti-inflammatory drug).

Description

Chemical name

  • 2-[5-ethyl-2-(2,3,5,6-tetrafluoroanilino)phenyl]acetic acid.

Molecular formula

  • C16H13F4NO2

Molecular weight

  • 327.27

Storage requirements

  • Store injectable preparation in a refrigerator (2-8°C).

Uses

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Indications

  • Cats: relief of pain and inflammation due to soft tissue surgery and acute pain and inflammation associated with musculoskeletal disorders.
  • Dogs: relief of pain and inflammation associated with chronic osteoarthritis Arthritis: osteoarthritis or treatment of acute pain Pain: management associated with soft tissue and orthopedic surgery.

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

  • Do not use together with non-steroidal anti-inflammatory drugs (NSAIDs) or corticosteroids, medicines commonly used in the treatment of pain, inflammation and allergies. Dogs and cats receiving ACE inhibitors and / or diuretics concurrently with robenacoxib should be monitored carefully for signs of hypotension that will increase the risk of renal side effects.

with diagnostic tests

  • Administration of NSAIDs commonly causes elevations in liver enzyme concentrations.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references fromPubMed.
  • King J N, Arnaud J P, Goldenthal E I, Gruet P, Jung M, Seewald W, Lees P (2011)Robenacoxib in the dog: target species safety in relation to extent and duration of inhibition of COX-1 and COX-2.J Vet Pharmacol Ther34, 298-311PubMed.
  • Reymond N, Speranza C, Gruet P, Seewald W, King J N (2011).Robenacoxib vs. carprofen for the treatment of canine osteoarthritis; a randomized noninferiority clinical trial.J Vet Pharmacol Therdoi: 10.1111/j.1365-2885.2011.01297.x. [Epub ahead of print]PubMed.
  • Gruet P, Seewald W, King J N (2011)Evaluation of subcutaneous and oral administration of robenacoxib and meloxicam for the treatment of acute pain and inflammation associated with orthopaedic surgery in dogs.Am J Vet Res72(2), 184-193PubMed.
  • Schmid V Bet al(2010)Analgesic and anti-inflammatory actions of robenacoxib in acute joint inflammation in dog.J Vet Pharmacol Ther33(2), 118-131PubMed.
  • Jung M, Lees P, Seewald W & King J N (2009)Analytical determination and pharmacokinetics of robenacoxib in the dog.J Vet Pharmacol Ther32(1), 41-48PubMed.

Other sources of information


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