ISSN 2398-2942      

Rifampicin

icanis
Contributor(s):

Sally Anne Argyle

Jo Murrell

Synonym(s): Rifampin


Introduction

Name

  • Rifampicin.

Class of drug

  • Rifampicin belongs to the class Rifamycin and is a bacteriocidal antibiotic that is a semi-synthetic derivative of the naturally occurring antibiotic rifamycin B.

Description

Chemical name

  • Rifampicin.

Molecular formula

  • C43H58N4O12

Molecular weight

  • 822.94

Uses

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Indications

  • It is particularly effective against Gram-positive organisms, some mycobacteria, Chlamydophila,Rickettsia Rickettsia rickettsii , some protozoans and poxviruses.
  • It is most commonly used to treatMycobacterium tuberculosis Mycobacterium tuberculosis ,RhodococcusandStaphylococciinfections Staphylococcus spp.
  • Gram-negative aerobic bacteria are usually resistant to rifampicin but obligate anaerobic bacteria are usually susceptible.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

  • Rifampicin is a potent hepatic P450 cytochrome enzyme inducer and increases rate of metabolism of other drugs in man including barbiturates, theophylline Theophylline and ketoconazole Ketoconazole. Increased dosages of these drugs may be required if used in combination with rifampicin.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • The Veterinary Formulary (2004) 6th edn. Ed: Bishop Y. British Veterinary Association and Royal Pharmaceutical Society.
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