Canis ISSN: 2398-2942

Quinidine

Introduction

Name

  • Quinidine.

Class of drug

  • Class 1a anti-arrhythmic agent.

Uses

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Indications

Administration

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Precautions

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Interactions

with other drugs



Digoxin
  • Digoxin levels may be increased by quinidine. It is recommended that the dose of digoxin be decreased by 1/2 when adding quinidine and that serum drug levels of both quinidine and digoxin be assessed. Deletion of Coumarin anticoagulants, eg warfarin and its interaction with Quinidine.
Neuromuscular blockers, eg atracurium, suxamethonium, tubocurarine
  • Effects may be enhanced by quinidine.
Drugs that alkalinize urine, eg antacids, carbonic anhydrase inhibitors, sodium bicarbonate, thiazide diuretics
  • Reduce the excretion of quinidine, thus prolonging its half-life.
Phenobarbitone or phenytoin
  • The half-life of quinidine may be reduced by as much as 50% as a consequence of hepatic enzyme induction by these drugs.
Cimetidine
  • Inhibits the metabolism of quinidine by inhibiting hepatic microsomal enzymes, thereby increasing its effect.
Anti-arrhythmic drugs, eg procainamide
  • Additive cardiac depressant effects and an increased risk of ventricular arrhythmias may result.
Verapamil
  • There is an increased risk of hypotension.

Adverse Reactions

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Further Reading

Publications

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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