Canis ISSN: 2398-2942

Propantheline

Contributor(s): Lauren Trepanier

Introduction

Name

  • Propantheline bromide.

Class of drug

  • Quarternary ammonium antimuscarinic agent.

Uses

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Indications

  • Incontinence caused by detrusor hyperreflexia.
  • May occasionally be useful in treating bradycardias.
  • A peripherally acting anti-emetic (not recommended).
  • Occasionally used as an adjunctive therapy to treat diarrhea (not recommended due to side effects of ilius).

Administration

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Precautions

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Interactions

with other drugs



Antihistamines, benzodiazepines, pethidine, phenothiazines, procainamide and quinidine
  • May enhance the activity of propantheline and its derivatives.
Chronic corticosteroid use (may increase intraocular pressure), disopyramide, nitrates and primidone
  • May potentiate the adverse effects of propantheline and its derivatives.
Nitrofurantoin, sympathomimetics and thiazide diuretics
  • Propantheline and its derivatives may enhance the actions.
Metoclopropamide
  • Propantheline and its derivatives may antagonize the actions.

Adverse Reactions

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Further Reading

Publications

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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