Canis ISSN: 2398-2942

Prochlorperazine

Contributor(s): Lauren Trepanier

Introduction

Name

  • Prochlorperazine.

Class of drug

  • Piperazine phenothiazine.
  • CNS dopamine receptor blocker.

Uses

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Indications

  • It is used predominantly to control motion sickness.

Administration

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Precautions

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Interactions

with other drugs



CNS depressant agents, eg anesthetics, narcotic analgesics
  • May cause additive CNS depression.
Quinidine
  • Given with phenothiazines may cause additive cardiac depression Quinidine.
Antacids or antidiarrheal preparations, eg bismuth subsalicylate or kaolin/pectin mixtures
  • May reduce gastrointestinal absorption of oral phenothiazines Aluminum antacid.
Propranolol
  • Increased blood levels of both drugs may result if propranolol Propranolol is administered with phenothiazines.
Epinephrine
  • Phenothiazines block alpha-adrenergic receptors which, may lead to unopposed beta activity causing vasodilation and increased cardiac rate Epinephrine.
Phenytoin
  • Phenytoin Phenytoin : metabolism may be decreased if given concurrently with phenothiazines.

Adverse Reactions

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Further Reading

Publications

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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