Canis ISSN: 2398-2942

Primidone

Synonym(s): 2-deoxybarbiturate

Contributor(s): Kyle Braund

Introduction

Name

  • Primidone.

Class of drug

  • Barbiturate derivative.

Description

Chemical name

  • 5-ethyldihydro-5-phenyl-4,6(1H,5H)-pyrimidinedione.

Molecular formula

  • C12H14N2O2.

Physical properties

  • Tablets.

Storage requirements

  • <25°C.

Uses

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Indications

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs



Oral acetazolamide
  • May decrease the gastrointestinal (GI) absorption of primidone Acetazolamide.
As the primary active metabolite for primidone is phenobarbitone the following drug interactions may be of clinical significance
  • Drugs increasing the effect of primidone:
    • Chloramphenicol Chloramphenicol.
    • Other central nervous system (CNS) depressants, eg antihistamines, narcotics, phenothiazines.
    • Valproic acid Sodium valproate.
  • Drugs affected by primidone (enhanced metabolism/decreased effect):
  • Griseofulvin Griseofulvin :
    • Primidone may decrease absorption; avoid giving them together.
  • Barbiturates:
    • May enhance the toxic effect of anti-epileptics.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Rambuck Bet al(1999)Concentrations of phenobarbital in epileptic dogs on phenobarbital or primidone therapy.Kleintierpraxis44(5), 345-354.
  • Trepanier L Aet al(1998)Therapeutic serum drug concentrations in epileptic dogs treated with potassium bromide alone or in combination with other anticonvulsants - 122 cases (1992-1996).JAVMA213(10), 1449-1453.

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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