Canis ISSN: 2398-2942

Pradofloxacin

Synonym(s): Veraflox®

Contributor(s): Gigi Davidson, Vetstream Ltd

Introduction

Name

  • Pradofloxacin.

Class of drug

  • Antibiotic.
  • Antimicrobial.
  • Fluoroquinolone.

Description

Chemical name

  • 8-Cyano-1-cyclopropyl-7-((1S,6S)-2,8-diazabicyclo[4.3.0]nonan-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid.

Molecular formula

  • C21H21FN4O3.

Molecular weight

  • 396.42

Storage requirements

  • <30°C.
  • In a dry environment.

Uses

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Indications

Other infections
  • Staphylococcus spp Staphylococcus sppPasturella spp Pasteurella multocidaBrucella spp Brucella canisChlamydia spp Chlamydia psittaciMycoplasma spp Mycoplasmas and ureaplasmas and some Mycobacteria spp Mycobacterium tuberculosis.
  • Enrofloxacin Enrofloxacin is effective against many beta-lactamase producing bacteria.
  • The fluoroquinolones are highly lipophilic drugs which attain high concentrations within the cells of many tissues and are particularly effective in the management of soft tissue, urogenital (including prostatic) and skin infections.
  • Compared to other fluoroquinolones Pradofloxacin has enhanced gram-positive aerobic activity.
  • Compared to other fluoroquinolones Pradofloxacin has enhanced activity against anaerobes and Mycoplasma spp (especially Mycoplasma haemofelis).

Administration

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Pharmocokinetics

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Precautions

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Interactions

With other drugs

Antibiotics

  • Combination with chloramphenicol Chloramphenicol, macrolide antibiotics or tetracyclines Tetracycline may produce antagonistic effects.

Anticoagulants

  • Fluoroquinolones may increase the anticoagulant effect of anticoagulants such as warfarin.

Adsorbent antacids (Mg, Al)

Oral cyclosporine

  • Fluoroquinolones may cause elevations of cyclosporine due to competitive metabolism.
  • Concurrent use of oral cyclosporine Ciclosporin with fluoroquinolones may cause transient elevations in creatinine and increase the risk of renal damage.

Sucralfate, iron, aluminium, and zinc salts

  • May inhibit absorption due to chelation; separate doses of these drugs by 6-8 hours.

Theophylline

  • Increases plasma theophylline levels Theophylline (in humans) - monitor carefully.

Dairy products (containing calcium)

  • May reduce bioavailability of fluoroquinolones.

NSAIDs (non-steroidal anti-inflammatory drugs)

  • Potential pharmacodynamic interactions in the CNS could lead to seizures (in susceptible animals).

Adverse Reactions

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Further Reading

Publications

Refereed Papers

  • Recent references from VetMed Resource and PubMed.
  • Hauschild G, Rohn K, Engelhardt E, Sager M, Hardes J, Gosheger G (2013) Pharmacokinetic study on pradofloxacin in the dog - Comparison of serum analysis, ultrafiltration and tissue sampling after oral administration. BMC Vet Res 9 PubMed.
  • Lees P (2013) Pharmacokinetics, pharmacodynamics and therapeutics of pradofloxacin in the dog and cat. J Vet Pharmacol Ther 36(3), 209-221 PubMed.
  • Korber-Irrgang B, Wetzstein H G, Bagel-Trah S, Hafner D, Kresken M (2012) Comparative activity of pradofloxacin and marbofloxacin against coagulase-positive staphylococci in a pharmacokinetic-pharmacodynamic model based on canine pharmacokinetics. J Vet Pharmacol Ther 35(6), 571-579 PubMed.

Other sources of information


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