Canis ISSN: 2398-2942

Potassium bromide

Contributor(s): Stephen Barr, Kyle Braund, Laurent Garosi

Introduction

Name

  • Potassium bromide.

Class of drug

  • Anticonvulsant.

Description

Molecular weight

  • 32.102.

Physical properties

  • White crystals.
  • Dissolves in water.

Uses

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Indications

  • Epilepsy Epilepsy: idiopathic , as an adjunct to phenobarbitone Phenobarbital when this has not produced complete control of seizures in dogs.
  • In epileptic dogs where there is evidence of pre-existing hepatic pathology or barbiturate toxicity, eg hepatotoxicity.

    Use with caution in patients with impaired renal function.

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

  • Bromide toxicity may occur if chloride ion ingestion is reduced, eg low salt diet. Conversely, additional sodium chloride in the diet can reduce serum bromide levels, affecting seizure control.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • March P Aet al(2002)Pharmacokinetics and toxicity of bromide following high-dose oral potassium bromide administration in healthy Beagles.J Vet Pharmacol Ther25, 425-432PubMed.
  • Trepanier L Aet al(1998)Therapeutic serum drug concentrations in epileptic dogs treated with potassium bromide alone or in combination with other anticonvulsants - 122 cases (1992-1996).JAMVA213(10), 1449-1453PubMed.
  • Nichols E S, Trepanier L A & Linn K (1996)Bromide toxicosis secondary to renal insufficiency in an epileptic dog.JAVMA208, 231-233PubMed.
  • Shaw N, Trepanier L A, Center S A & Garland S (1996)High dietary chloride content associated with loss of therapeutic serum bromide concentrations in an epileptic dog.JAVMA208, 234-236PubMed.
  • Trepanier L A (1995)Use of bromide as an anticonvulsant for dogs with epilepsy.JAVMA207, 163-166.
  • Podell M & Fenner WR (1993)Bromide therapy in refractory canine idiopathic epilepsy.JVIM7, 318-327.

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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