Canis ISSN: 2398-2942

Phenylpropanolamine - diphenylpyraline

Synonym(s): PPA

Contributor(s): Lauren Trepanier

Introduction

Name

  • Phenylpropanolamine.

Class of drug

  • Sympathomimetic amine.

Description

Chemical name

  • 4-(diphenylmethoxy)-1-methylpiperidine.

Molecular formula

  • C19H23NO.

Physical properties

  • Clear liquid.

Storage requirements

  • <25°C.
  • In a dry environment.
  • Do not store in fridge.

Uses

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Indications

Administration

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Pharmocokinetics

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Precautions

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Interactions

with other drugs

  • Monoamine oxidase (MAO) inhibitors - do not give PPA within 2 weeks of MAO inhibitors.
  • Avoid with other sympathomimetics, eg ephedrine, epinephrine Epinephrine.
  • Avoid use with concurrent NSAIDs as may increase risk of hypertension.
  • Can cause cardiac arrhythmias if given with halogenated hydrocarbon anesthetic agents.

Adverse Reactions

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Further Reading

Publications

Refereed papers

  • Recent references fromPubMed.
  • Scott L, Leddy M, Bernay F and Davot J L (2002)Evaluation of phenylpropanolamine in the treatment of urethral sphincter mechanism incompetence in the bitch.JSAP43, 493-496PubMed.

Other sources of information

  • Plumb D C (2002)Veterinary Drug Handbook. 4th edn. Iowa State University Press, Ames, Iowa.
  • Tennant B (1999) Small Animal Formulary.3rd edn. Cheltenham: BSAVA.

ADDED