Canis ISSN: 2398-2942

Phenylbutazone

Contributor(s): Kyle Braund

Introduction

Name

  • Phenylbutazone.

Class of drug

Description

Chemical name

  • 4-butyl-1,2-diphenyl-3,5-pyrazolidinedione.

Molecular formula

  • C19H20N2O2.

Physical properties

  • Tablets.

Storage requirements

  • <25°C.
  • In a dry environment.
  • Protect from light.

Uses

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Indications

Administration

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Precautions

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Interactions

with other drugs

Fluoroquinolones
  • In man there is an increased risk of convulsions when used concomitantly.
Anti-hypertensives, eg beta-blockers
  • NSAIDs may antagonize the hypotensive effects.
Protein-bound drugs, eg coumarins, anesthetics
  • Phenylbutazone displaces a wide variety of protein-bound drugs, thereby potentiating their effects.

with diagnostic tests

  • Phenylbutazone may cause false low T3 and T4 values.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Watson A D J et al (1996) Use of anti-inflammatory and analgesic drugs in dogs and cats. Aust Vet J 74(3), 203-210.

Other sources of information

  • Based on Small Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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