Canis ISSN: 2398-2942

Phenoxymethylpenicillin

Synonym(s): Penicillin V

Introduction

Name

  • Phenoxymethylpenicillin.

Class of drug

  • Penicillin antibiotic.

Description

Chemical name

  • [2S-(2-alpha,5-alpha,6-beta)]-3,3-dimethyl-7-oxo-6-[(phenoxyacetyl)amino]4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid.
  • 6-phenoxyacetamidopenicillanic acid.

Molecular formula

  • C16H18N2O5S.

Physical properties

  • Tablets.
  • Solution.

Uses

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Indications

  • Penicillin V is orally administered as it is more resistant to acid degradation than penicillin G and is better absorbed.
  • As penicillin V has a narrow spectrum of activity, its use is limited to the treatment of infections caused byStreptococcusspp Streptococcus spp ,Clostridiumspp Clostridia spp ,Borrelia borgderferi Borrelia burgdorferi , and fusospirochetes.
  • Serious infections should be treated with parenteral penicillin G Benzylpenicillin as the absorption of penicillin V is unpredictable. Penicillin V may be used later in the course of therapy.
  • When used for 'blind' therapy of undiagnosed serious infections penicillins may be administered with gentamicin Gentamicin and/or metronidazole Metronidazole.

Administration

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Precautions

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Interactions

with other drugs



Probenecid
  • Blocks the renal tubular excretion, producing higher and more prolonged plasma concentrations.

Further Reading

Publications

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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