Canis ISSN: 2398-2942

Phenoxybenzamine

Synonym(s): Dibenyline

Contributor(s): Lauren Trepanier

Introduction

Name

  • Phenoxybenzamine.

Class of drug

  • Non-selective alpha-adrenergic receptor antagonist (alpha blocker).

Description

Chemical name

  • N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzenemethanamine.
  • N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzylamine.

Molecular formula

  • C18H22ClNO.

Physical properties

  • Capsules.

Uses

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Indications

  • Treatment of reflex dyssynergia in small animals.
  • Treatment of urethral spasm in cats with FLUTD.
  • Severe hypertension in animals with phaeochromocytoma Pheochromocytoma prior to surgery (in conjunction with a beta-blocker).

Administration

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Pharmocokinetics

Precautions

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Interactions

with other drugs



Beta-blockers and diuretics
  • There is an increased risk of a first-dose hypotensive effect with beta-blockers and diuretics.

Adverse Reactions

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Further Reading

Publications

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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