ISSN 2398-2942      

Phenoxybenzamine

icanis

Synonym(s): Dibenyline


Introduction

Name

  • Phenoxybenzamine.

Class of drug

  • Non-selective alpha-adrenergic receptor antagonist (alpha blocker).

Description

Chemical name

  • N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzenemethanamine.
  • N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzylamine.

Molecular formula

  • C18H22ClNO.

Physical properties

  • Capsules.

Uses

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Indications

  • Treatment of reflex dyssynergia in small animals.
  • Treatment of urethral spasm in cats with FLUTD.
  • Severe hypertension in animals with phaeochromocytoma Pheochromocytoma prior to surgery (in conjunction with a beta-blocker).

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

Beta-blockers and diuretics

  • There is an increased risk of a first-dose hypotensive effect with beta-blockers and diuretics.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Ramsey I (2017) BSAVA Small Animal Formulary. 9th edn.
  • Based on Small Animal Formulary.Tennant, Bryn (1999) 3rd edn. BSAVA, UK.
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