Canis ISSN: 2398-2942

Pethidine

Synonym(s): Meperidine hydrochloride

Contributor(s): Sheilah Robertson

Introduction

Name

  • Pethidine.

Class of drug

  • Opioid analgesic.
  • Synthetic µ agonist.
  • Scheduled drug (controlled substance).

Description

Chemical name

  • 1-methyl-4-phenyl-4-piperidinecarboxylic acid ethyl ester.
  • 1-methyl-4-phenylisonipecotic acid ethyl ester.

Molecular formula

  • C15H21NO2.

Physical properties

  • Tablets.
  • Solution.

Uses

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Indications

  • An opioid analgesic Analgesia: opioid which provides prompt but short-term analgesia Analgesia: overview :
    • Onset of action 10-15 min.
    • Duration of action </= 2 h (most references site <2 h).
  • Less potent than morphine Morphine in its analgesic and respiratory depressant effects.
  • Pethidine is preferred to morphine for control of pain with pancreatitis Pancreatitis: acute.
  • Can produce very good sedation in young animals (puppies).

Administration

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Precautions

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Interactions

with other drugs

Central nervous system (CNS) depressants (anesthetics, anti-histamines, barbiturates, phenothiazines, tranquilizers)
  • Increased CNS or respiratory depression.
Cimetidine Cimetidine
  • The metabolism of pethidine is inhibited thereby increasing plasma concentrations Cimetidine.

with diagnostic tests

Plasma amylase and lipase
  • As narcotic analgesics may increase biliary tract pressure, levels may be increased for up to 24 hours after narcotic administration (increased biliary tract pressure).

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Biricik H S, Ceylan C & Sakar M (2004)Effects of pethidine and fentanyl on tear production in dogs.Vet Rec.155, 564-565.

Other sources of information

  • Based onSmall Animal Formulary.Tennant Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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