Canis ISSN: 2398-2942

Pentobarbital

Synonym(s): Pentobarbitone

Contributor(s): Sheilah Robertson

Introduction

Name

  • Pentobarbital sodium.

Class of drug

  • Short-acting barbiturate.

Description

Chemical name

  • 5-ethyl-5-(1-methylbutyl)-2,4,6(1H,3H,5H)-pyrimidinetrione.
  • 5-ethyl-5-(1-methylbutyl)barbituric acid.

Molecular formula

  • C11H18N2O3.

Physical properties

  • Non-sterile aqueous solution.

Storage requirements

  • Protect from light.

Uses

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Indications

  • A short-acting barbiturate which may be used as an IV anaesthetic, as an anticonvulsant to treat acute seizures or for euthanasia.

Administration

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Precautions

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Interactions

with other drugs



Drugs which may increase the effect of pentobarbital
  • Chloramphenicol Chloramphenicol.
  • Other central nervous sytem (CNS) depressants (antihistamines, narcotics, phenothiazines).
  • Valproic acid Sodium valproate.
Drugs acted on by pentobarbital (enhanced metabolism/decreased effect)Barbiturates
  • May enhance the effects of other anti-epileptics.

Further Reading

Publications

Other sources of information

  • Based onSmall Animal Formulary.Tennant Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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