Canis ISSN: 2398-2942

Penicillamine

Introduction

Name

  • Penicillamine.

Class of drug

  • Oral chelating agent.

Description

Chemical name

  • 3-mercapto-D-valine.

Molecular formula

  • C5H11NO2S.

Physical properties

  • Tablets.

Uses

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Indications

  • Used in humans for the treatment of rheumatoid arthritis (mechanism unknown).
  • In dogs it has been used mainly for treating copper-associated hepatopathy in the Bedlington Terrier Copper toxicosis (Bedlington Terrier) and the oral treatment of lead poisoning Lead toxicity.
  • It has also been used in the treatment of primary biliary cirrhosis, idiopathic chronic active hepatitis Liver: chronic hepatitis and cystinurea (decreases cystine excretion by combining with cystine to form the soluble complex cystine-D-penicillamine disulfide).
  • May also be used in the management of lead toxicity in birds when injecting EDTA is too difficult or long term chelation is required.

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs



Drugs decreasing the absorption of penicillamine
Cytotoxic drugs
  • An increase in the renal and hematologic effects of penicillamine have been recorded in people.
Gold
  • An increase in the renal and hematologic effects of penicillamine have been recorded in people.
Phenylbutazone
  • An increase in the renal and hematologic effects of penicillamine have been recorded in people Phenylbutazone.

Adverse Reactions

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Further Reading

Publications

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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