Canis ISSN: 2398-2942

Pancuronium

Contributor(s): John Dodam

Introduction

Name

  • Pancuronium.

Class of drug

  • Non-depolarizing neuromuscular blocking agent.

Uses

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Indications

  • Profound skeletal muscle relaxation when modest cardiovascular stimulation required.
  • In patients undergoing mechanical ventilation.

Administration

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Pharmocokinetics

Precautions

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Interactions

with other drugs


Drugs which may antagonize the effects of pancuroniumSuxamethonium
  • May enhance muscular relaxation (delay the administration of pancuronium until the effects of suxamethonium begin to diminish) Suxamethonium.
Drugs which may enhance the action of pancuronium
  • Some antibiotics, eg aminoglycosides, clindamycin Clindamycin , lincomycin Lincomycin.
  • Inhalational anesthetics, eg halothane Halothane , methoxyflurane Methoxyflurane.
    Duration of action is longer when isoflurane Isoflurane
    rather than halothane is used to maintain anethesia.
  • Magnesium salts.
  • Quinidine Quinidine.

Adverse Reactions

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Further Reading

Publications

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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