Canis ISSN: 2398-2942
Neostigmine
Contributor(s): Kyle Braund
Introduction
Name
Class of drug
Description
Chemical name
- 3-[[(dimethylamino)carbonyl]oxy]-N,N,N-trimethylbenzenaminium.
Molecular formula
Physical properties
Uses
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Indications
- Inhibits acetylcholinesterase thereby prolonging the action of acetylcholine. Slower onset but longer duration of action than edrophonium Edrophonium.
- Used to treat acute myasthenic crises Myasthenia gravis when difficulty in breathing and swallowing (megaesophagus) are seen.
- Is also be used to reverse the action of non-depolarizing neuromuscular blocking agents. Most useful when long acting neuromuscular blocking agents such as pancuronium Pancuronium have been used.
Administration
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Precautions
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Interactions
with other drugs
- Aminoglycosides, clindamycin Clindamycin , lincomycin Lincomycin , polymyxins Polymyxin B and propranolol Propranolol may antagonize the effect of neostigmine.
- Neostigmine enhances the effect of suxamethonium Suxamethonium but antagonises the effect of non-depolarizing muscle relaxants.
Adverse Reactions
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Further Reading
Publications
Other sources of information
- Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.