Canis ISSN: 2398-2942

Neomycin

Introduction

Name

  • Neomycin.

Class of drug

  • Aminoglycoside antibiotic.

Description

Physical properties

  • Tablets.
  • Suspension/sterile aqueous suspension.
  • Pale yellow oily suspension.
  • Cream.

Storage requirements

  • Tablets:
    • <25°C.
    • In a tightly closed container.
  • Suspension:
    • Refrigerate between 2-8°C.
    • Protect from light.
    • Do not freeze.
  • Oily suspension/cream:
    • <25°C.
    • Do not store in fridge.
    • Protect from light.

Uses

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Indications

  • Gram-negative infections.
  • Some staphylococcal Staphylococcus spp and streptococcal Streptococcus spp (fecalis) infections.
    All obligate anaerobic bacteria and many haemolytic streptococci are resistant.
  • As neomycin is extremely nephrotoxic and ototoxic it is:
    • Primarily used topically for infections of skin, ear or mucus membranes, or orally to reduce intestinal bacterial population in treating hepatic encephalopathy and before intestinal surgery.
    • Non-specific bacterial enteritides - often in combination with antimuscarinic agents.
    • Treatment of hepatic encephalopathy (coma) together with dietary protein reduction and lactulose Lactulose : 20 mg/kg PO QID.
    • To reduce bacterial flora before elective colorectal surgery (along with appropriate bowel evacuation): 500 mg-1 g (with an identical dose of erythromycin Erythromycin base) 19 hours, 18 hours and 9 hours before surgery.

    This dosage regimen is derived from human data. Differences in gastrointestinal (GI) transit times may alter the dosing schedule in dogs.

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs



Drugs affected by neomycin (decreased absorption)
Ototoxic and nephrotoxic drugs, eg frusemide, gentamicin and polymyxin B

Adverse Reactions

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Further Reading

Publications

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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