ISSN 2398-2942      

Naloxone

icanis

Introduction

Name

  • Naloxone.

Class of drug

  • Opioid antagonist.

Description

Chemical name

  • (5-alpha)-4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-one.
  • 17-allyl-4,5-alpha-epoxy-3,14-dihydroxymorphinan-6-one.

Molecular formula

  • C19H21NO4.

Physical properties

  • Solution.

Uses

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Indications

  • Indicated for treatment of gross overdosage of all opioids including agonist/antagonists, eg butorphanol, nalbuphine.
  • Has been used in the management shock (high doses).
  • Has been used to treat Electromechanical Dissociation (EMD) in cardiac arrest.
  • To identify persistent opioid activity (a small IV dose will give transient increase in consciousness when persistent opioid activity contributes to prolonged anesthetic recovery).

Administration

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Precautions

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Interactions

with other drugs

Opioids

  • The sedative effects may persist longer than that of naloxone, therefore monitor animals being treated for overdose carefully, until the sedative effects remain negated.
  • Naloxone will also reverse the analgesic effects of opioids.

Publications

Refereed papers

Other sources of information

  • Ramsey I (2017) BSAVA Small Animal Formulary. 9th edn. 
  • Based on Small Animal Formulary. Tennant B (1999) 3rd edn. BSAVA, UK.
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