ISSN 2398-2942      

Mycophenolate mofetil

icanis
Contributor(s):

Vetstream Ltd

Gigi Davidson

Synonym(s): MMF


Introduction

Name

  • Mycophenolate mofetil.

Class of drug

  • Immunosuppressant.

Description

Chemical name

  • 2-morpholinoethyl (E)-6-(1,3-­dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4­-hexenoate

Molecular formula

  • C23H31NO7

Molecular weight

  • 433.50

Physical properties

  • Oral: 250 mg capsules, 500 mg tablets,1 g/5 ml powder for oral suspension; 180 mg, 360 mg tablets.
  • Injectable: 500 mg powder for reconstitution and slow IV infusion.

Storage requirements

  • Capsules, tablets and injections: 25°C. Discard reconstituted injection after 7 days.
  • Reconstituted oral suspension: 4°C or 25°C. Discard reconstituted suspension after 60 days.

Uses

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Indications

Administration

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Pharmacokinetics

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Precautions

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Interactions

With other drugs

  • Competes with other drugs that undergo active renal tubular secretion resulting in increased concentration of either drug.
  • Concomitant administration of antacids (eg omeprazole Omeprazole) may decrease absorption.
  • May interfere with antibody response to vaccination.

With diagnostic tests

  • May elevate blood glucose concentrations.

Adverse Reactions

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Further Reading

Publications

Refereed Papers

  • Recent references from VetMedResource and PubMed.
  • Ackermann A L, May E R, Frank L A (2017) Use of mycophenolate mofetil to treat immune-mediated skin dosease in 14 dogs - a retrospective evaluation. Vet Dermatol 28(2), 195-e44 PubMed.
  • Cummings F O, Rizzo S A (2017) Treatment of presumptive primary immune-mediated thrombocytopenia with myophenolate mofetil versus cyclosporine in dogs. JSAP 58(2), 96-102 PubMed.
  • Barnoon I, Shamir M H, Aroch I, Bdolah-Abram T, Srugo I, Konstantin L, Chai O (2016) Retrospective evaluation of combined mycophenolate mofetil and prednisone treatment for meningoencephalomyelitis of unknown etiology in dogs: 25 cases (2005-2011). J Vet Emerg Crit Care (San Antonio) 26(1), 116-124 PubMed.
  • Woolcock A D, Wang A, Haley A et al (2016) Treatment of canine meningoencephalomyelitis of unknown aetiology with mycophenolate mofetil and corticosteroids: 25 cases (2007-2012). Vet Med Sci 2(2), 125-135 PubMed
  • IRIS Canine GN Study Group Established Pathology Subgroup, Segev G, Cowgill L D, Heiene R, Labato M A, Polzin D J  (2013) Consensus recommendations for immunosuppressive treatment of dogs with glomerular disease based on established pathology. J Vet Intern Med 27 Suppl 1, S44-54 PubMed.
  • Yau V K, Bianco D (2013) Treatment of five haemodynamically stable dogs with immune-mediated thrombocytopenia using mycophenolate mofetil as single agent. J Vet Intern Med 27 Suppl 1, S44-54 PubMed.
  • West L D, Hart J R (2014) Treatment of idiopathic immune-mediated hemolytic anemia with mycophenolate mofetil in five dogs. J Vet Emerg Crit Care (San Antonio) 24(2), 226-31 PubMed.
  • Downing H J, Pirmohamed M, Beresford M W, Smyth R L (2013) Paediatric use of mycophenolate mofetil. Br J Clin Pharmacol 75(1), 45-59 PubMed.
  • Wang A, Smith J R, Creevy K E (2013) Treatment of canine idiopathic immune-mediated haemolytic anaemia with mycophenolate mofetil and glucocorticoids: 30 cases (2007 to 2011). JSAP 54(8), 399-404 PubMed.
  • Whitley N T, Day M J (2011) Immunomodulatory drugs and their application to the management of canine immune-mediated disease. JSAP52(2), 70-85 PubMed.
  • Dewey C W, Cerda-Gonzalez S, Fletcher D J, Harb-Hauser M F, Levine J M, Badgley B L, Olby N J, Shelton G D (2010) Mycophenolate mofetil treatment in dogs with serologically diagnosed acquired myasthenia gravis: 27 cases (1999-2008). JAVMA 236(6), 664-668 PubMed.

Other sources of information

  • Ramsey I (2017) BSAVA Small Animal Formulary. 9th edn BSAVA, UK.
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