Canis ISSN: 2398-2942

Morphine

Contributor(s): John Dodam, Sheilah Robertson, Jo Murrell

Introduction

Name

  • Morphine.

Class of drug

Description

Chemical name

  • (5-alpha,6-alpha)-7,8-didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol.

Molecular formula

  • C17H19NO3

Physical properties

  • Tablets.
  • Solution.

Storage requirements

Uses

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Indications

Not licensed in the UK – methadone Methadone is licensed and is a suitable alternative to morphine for premedication and peri-operative analgesia.

Administration

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Precautions

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Interactions

with other drugs

CNS depressants (anesthetics, antihistamines, barbiturates, phenothiazines, tranquilizers)

  • Enhanced central nervous system (CNS) or respiratory depression may occur.

with diagnostic tests

Plasma amylase or lipase

  • As narcotic analgesics can increase biliary tract pressure, levels may be increased for up to 24 hours after drug administration.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Monteiro E R, Rabello T A, Rangel J P P, Nunes J S Jr, Freire C D, Campagnol D (2019) Effects of 3 morphine doses, in combination with acepromazine, on sedation and some physiological parameters in dogs. Can J Vet Res 83(3), 235-240 PubMed.
  • Nishimura L T, Auckburally A, Santilli J, Vieira B H B, Garcia D O, Honsho C S, de Mattos-Junior E (2018) Effects of dexmedetomidine combined with commonly administered opioids on clinical variables in dogs. Am J Vet Res 79(3), 267-275 PubMed.

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