Canis ISSN: 2398-2942

Mitotane

Synonym(s): op'-DDD, Lysodren

Introduction

Name

  • Mitotane.

Class of drug

  • Dicophane (DDT) derivative.

Description

Chemical name

  • 1-chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]benzene.
  • 1,1-dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane.

Molecular formula

  • C14H10Cl4.

Uses

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Indications

  • Mitotane is used to treat hyperadrenocorticism (HAC) (Cushing's syndrome) Hyperadrenocorticism.
  • In the UK, Milotane has been superceded by Trilostane Trilostane in the treatment of HAC.

Administration

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Pharmocokinetics

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Precautions

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Adverse Reactions

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Further Reading

Publications

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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