Canis ISSN: 2398-2942

Midazolam

Contributor(s): Sheilah Robertson

Introduction

Name

  • Midazolam.

Class of drug

  • Water-soluble, short-acting benzodiazepine.

Uses

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Indications

  • Pre-operative sedative agent.
  • Unreliable sedation on its own, although it will sedate depressed animals.

Administration

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Precautions

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Interactions

With other drugs

Antihistamines, barbiturates, opioid analgesics, or other central nervous system depressants
  • Concurrent use may enhance the sedative effect.
Opioid analgesics, eg pethidine
  • May increase the hypnotic and hypotensive effects of midazolam.
  • Midazolam has very few hypotensive effects.
  • Midazolam has good cardiovascular stability.
Inhalational anesthetics
  • Decrease the dosages required.
Erythromycin
  • Inhibits the metabolism of midazolam.

Adverse Reactions

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Further Reading

Publications

Referred papers

Other sources of information

  • Based on Tennant B (1999) Small Animal Formulary. 3rd edn. Cheltenham: BSAVA.

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