Canis ISSN: 2398-2942

Midazolam

Contributor(s): Sheilah Robertson, Jo Murrell

Introduction

Name

  • Midazolam.

Class of drug

Uses

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Indications

  • Pre-operative sedative agent.
  • Unreliable sedation on its own, although it will sedate depressed animals.
  • Use as a co-induction agent with alfaxalone Alfaxalone or propofol Propofol.
  • Midazolam has very few hypotensive effects.
  • Midazolam has good cardiovascular stability.

Administration

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Precautions

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Interactions

With other drugs

Antihistamines, barbiturates, opioid analgesics, or other central nervous system depressants

  • Concurrent use may enhance the sedative effect.

Opioid analgesics, eg methadone

  • May increase the hypnotic and hypotensive effects of midazolam.

Erythromycin

  • Inhibits the metabolism of midazolam.

Adverse Reactions

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Further Reading

Publications

Referred papers

  • Recent references from VetMedResource and PubMed.
  • Kropf J, Hughes J L (2019) Effect of midazolam on the quality and duration of anaesthetic recovery in healthy dogs undergoing elective ovariohysterectomy or castration. Vet Anaesth Analg 46(5), 587-596 PubMed
  • Miller C, Hughes E, Gurney M (2019) Co-induction of anaesthesia with alfaxalone and midazolam in dogs: a randomized, blinded clinical trial. Vet Anaesth Analg 46(5), 613-619 PubMed.
  • Le Chevallier D, Slingsby L, Murrell J (2019) Use of midazolam in combination with medetomidine for premedication in healthy dogs. Vet Anaesth Analg 46(1), 74-78 PubMed.
  • Le Chevallier D, Slingsby L, Murrell J C (2018) Randomised clinical trial comparing clinically relevant sedation outcome measures in dogs after intramuscular administration of medetomidine in combination with midazolam or butorphanol for routine diagnostic imaging procedures. Vet J 239, 30-34 PubMed

Other sources of information

  • Based on Tennant B (1999) Small Animal Formulary. 3rd edn. Cheltenham: BSAVA.

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