Canis ISSN: 2398-2942

Metoclopramide

Contributor(s): Lauren Trepanier

Introduction

Name

  • Metoclopramide.

Class of drug

  • Anti-emetic.
  • Upper gastrointestinal tract stimulant.

Description

Chemical name

  • 4-amino-5-chloro-N-[(2-diethylamino)ethyl]-2-methoxybenzamide.
  • 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-o-anisamide.

Molecular formula

  • C14H22ClN3O2.

Physical properties

  • Tablets.

Storage requirements

  • In a dry environment.
  • Protect from light.

Uses

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Indications

  • Acts as an anti-emetic and an upper gastrointestinal (GI) stimulant.
  • Management of gastrointestinal reflux.

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs



Antimuscarinic drugs, eg atropine and narcotic analgesics
  • The activity of metoclopropamide may be inhibited Atropine.
Insulin
  • The absorption of food may be accelerated thereby altering insulin Insulin requirements and/or timing of its effects.
Phenothiazines
  • May potentiate the extrapyramidal effects of metoclopramide.
Narcotics, sedatives or tranquilizers
  • The central nervous system (CNS) effects of metoclopramide may be enhanced.

Adverse Reactions

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Further Reading

Publications

Other sources of information

  • Based on Tennant B (1999)Small Animal Formulary.3rd edn. Cheltenham: BSAVA.

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