Canis ISSN: 2398-2942

Metoclopramide

Contributor(s): Lauren Trepanier, Vetstream Ltd

Introduction

Name

  • Metoclopramide.

Class of drug

  • Anti-emetic.
  • Upper gastrointestinal tract stimulant.

Description

Chemical name

  • 4-amino-5-chloro-N-[(2-diethylamino)ethyl]-2-methoxybenzamide.
  • 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-o-anisamide.

Molecular formula

  • C14H22ClN3O2.

Physical properties

  • Tablets.

Storage requirements

  • In a dry environment.
  • Protect from light.

Uses

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Indications

  • Acts as an anti-emetic and an upper gastrointestinal (GI) stimulant.
  • Management of gastrointestinal reflux.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

Antimuscarinic drugs, eg atropine and narcotic analgesics

  • The activity of metoclopropamide may be inhibited Atropine.

Insulin

  • The absorption of food may be accelerated thereby altering insulin Insulin requirements and/or timing of its effects.

Phenothiazines

  • May potentiate the extrapyramidal effects of metoclopramide.

Narcotics, sedatives or tranquilizers

  • The central nervous system (CNS) effects of metoclopramide may be enhanced.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • BSAVA Small Animal Formulary. Ramsey I (2017) 9th edn. 

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