ISSN 2398-2942      

Mavacoxib

icanis
Contributor(s):

Jo Murrell

Vetstream Ltd

Synonym(s): Trocoxil


Introduction

Name

  • Mavacoxib.

Class of drug

  • NSAID (non-steroidal anti-inflammatory drug).

Description

Chemical name

  • 4-[5-(4-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide.

Physical properties

  • Off-white powder. Available as a chewable tablet preparation.

Storage requirements

  • Light sensitive - store in original container.

Uses

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Indications

  • Treatment of pain and inflammation associated with degenerative joint disease in dogs where continuous analgesia treatment for one month or more is required. Dogs must be at least one year of age and heavier than 5 kg bodyweight.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

  • Do not use with glucocorticosteroids or other NSAIDs. Dogs receiving ACE inhibitors and / or diuretics concurrently with mavacoxib should be monitored carefully for signs of hypotension that will increase the risk of renal side effects.

with diagnostic tests

  • Administration of NSAIDs commonly causes elevations in liver enzyme concentrations.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Cox S R et al (2010) The pharmacokinetics of mavacoxib, a long-acting COX-2 inhibitor, in young adult laboratory dogs. J Vet Pharmacol Ther 33 (5), 461-470 PubMed.
  • Cox S R et al (2011) Population pharmacokinetics of mavacoxib in osteoarthritic dogs.J  Vet Pharmacol Ther 34 (1), 1-11 PubMed.

Other sources of information

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