ISSN 2398-2942      

Masitinib

icanis
Contributor(s):

Gerry Polton

Vetstream Ltd

Synonym(s): Masivet


Introduction

Name

  • Masitinib.

Class of drug

  • Protein-tyrosine kinase inhibitor.

Description

Chemical name

  • Masitinib.

Molecular formula

  • C28H30N6OS

Molecular weight

  • 498.64

Physical properties

  • Film-coated tablet.

Storage requirements

  • No special storage conditions required.

Uses

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Indications

  • Treatment of non-resectable canine mast cell tumors Skin: mastocytoma (Grade 2 or 3) withconfirmedmutation of the c-kit tyrosine kinase receptor.
  • For any mast cell tumor treatable by surgery, surgery should be the first choice of treatment.

Administration

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Pharmacokinetics

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Precautions

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Interactions

with other drugs

  • Caution is advised with concurrent use of masitinib and other substances.
  • Concurrent use of other substances with a high degree of protein binding may compete with mastinib binding and thus cause adverse effects.
  • The efficacy of masitinib might be reduced in dogs previously treated with chemotherapy Mast cell tumor: chemotherapy protocols and/or radiotherapy Radiotherapy.

Adverse Reactions

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Hahn K A, Oglivie G, Rusk T, Devauchelle P, Leblanc A, Legendre A, Powers B, Leventhal P S, Kinet J P, Palmerini F, Dubreuil P, Moussy A, Hermine O (2008) Masitinib is safe and effective for the treatment of canine mast cell tumors. J Vet Int Med 22 (6), 1301-1309 PubMed.

Other sources of information

MEMBER BENEFIT

Can’t find what you’re looking for?

We have an ever growing content library on Vetlexicon so if you ever find we haven't covered something that you need please fill in the form below and let us know!

 
 
 
 

To show you are not a Bot please can you enter the number showing adjacent to this field

 Security code