Canis ISSN: 2398-2942

Marbofloxacin

Introduction

Name

  • Marbofloxacin.

Class of drug

  • Antibiotic.
  • Fluoroquinolone.

Uses

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Indications



Infections
  • Effective against mycoplasmas and many gram-positive and gram-negative organisms includingPasteurellaspp,Staphylococcusspp,Pseudomonas aeruginosa, Klebsiellaspp,Escherichia coli, Proteusspp andSalmonellaspp.
  • Aerobic.
  • Ineffective against anaerobic infections.
  • Fluoroquinones are highly lipophilic and atain high concentrations within cells in many tissues.
  • Particularly effective in soft tissue, urogenital (including prostatitis) and skin infections.

Administration

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Precautions

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Interactions

with other drugs



Adsorbents and antacids
  • Containing cations (Mg, Al) may bind to fluoroquinolones and prevent their absorption from the GIT Aluminum antacid.
Sucralfate and zinc salts
  • May inhibit the absorption of fluoroquinolones, separate doses of these drugs by at least 2 hours Sucralfate.
Theophylline
  • Fluoroquinolones increase plasma theophylline concentrations Theophylline.
Probenecid
  • Blocks the tubular secretion of fluoroquinolones and may increase their blood level and half-life.

Adverse Reactions

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Further Reading

Publications

Refereed papers

  • Carlotti D N, Guaguere E, Pin D, Jasmin P, Thomas E & Guiral V (1999)Therapy of difficult cases of canine pyoderma with marbofloxacin - a report of 39 dogs.JSAP40(6), 265-270.

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

ADDED