Canis ISSN: 2398-2942

Marbofloxacin

Contributor(s): Vetstream Ltd

Introduction

Name

  • Marbofloxacin.

Class of drug

  • Antibiotic.
  • Fluoroquinolone.

Uses

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Indications

Infections

  • Effective against mycoplasmas and many gram-positive and gram-negative organisms including Pasteurella spp, Staphylococcus spp, Pseudomonas aeruginosa, Klebsiella spp, Escherichia coli, Proteus spp and Salmonella spp.
  • Aerobic.
  • Ineffective against anaerobic infections.
  • Fluoroquinones are highly lipophilic and atain high concentrations within cells in many tissues.
  • Particularly effective in soft tissue, urogenital (including prostatitis) and skin infections.

Administration

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Precautions

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Interactions

with other drugs

Adsorbents and antacids

  • Containing cations (Mg, Al) may bind to fluoroquinolones and prevent their absorption from the GIT Aluminum antacid.

Sucralfate and zinc salts

  • May inhibit the absorption of fluoroquinolones, separate doses of these drugs by at least 2 hours Sucralfate.

Theophylline

  • Fluoroquinolones increase plasma theophylline concentrations Theophylline.

Probenecid

  • Blocks the tubular secretion of fluoroquinolones and may increase their blood level and half-life.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Carlotti D N, Guaguere E, Pin D, Jasmin P, Thomas E & Guiral V (1999) Therapy of difficult cases of canine pyoderma with marbofloxacin - a report of 39 dogs. JSAP 40(6), 265-270.

Other sources of information

  • Based on Small Animal Formulary. Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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