ISSN 2398-2942      

Lotilaner

icanis

Synonym(s): Credelio®


Introduction

Name

  • Lotilaner.

Class of drug

  • Ectoparasiticide.
  • Isoxazoline.

Description

Chemical name

  • 5-[(5S)-4,5-dihydro-5-(3,4,5-trichlorophenyl)- 5-(trifluoromethyl)-3-isoxazolyl]-3-methyl-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]- 2-thiophenecarboxamide

Molecular formula

  • C20H14Cl3F6N3O3S

Molecular weight

  • 596.75

Physical properties

  • Chewable tablet (white to beige round tablet with brownish spots).

Storage requirements

  • Does not have any special storage conditions.
  • Shelf life: 2 years.

Uses

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Indications

Administration

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Pharmacokinetics

Precautions

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Interactions

With other drugs

  • None known.
  • During clinical testing, no interactions were observed between lotilaner and vaccines, anthelmintics, antibiotics, steroids, NSAIDS, anesthetics, and antihistamines.

Adverse Reactions

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Further Reading

Publications

Refereed Papers

  • Recent references from VetMedResource and PubMed.
  • Baker K, Ellenberger C, Murphy M, Cavalleri D, Seewald W, Drake J, Nanchen S, Hacket K (2018) Laboratory evaluations of the 3-month efficacy of oral lotilaner (Credelio™) against experimental infestations of dogs with the Australian paralysis tick, Ixodes holocyclus. Parasites & Vectors 11, 487 PubMed Full article.
  • Lasmar P V F, Murphy M, Nanchen S, Drake J, Coumendouros K, Borges D A, de Oliveira P C, Scott F B (2018) Laboratory evaluation of the efficacy of lotilaner (Credelio™) against Amblyomma cajennense (sensu lato) infestations of dogs. Parasites & Vectors 11, 537 PubMed Full article.
  • Otaki H, Sonobe J, Murphy M, Cavalleri D, Seewald W, Drake J, Nanchen S (2018) Laboratory evaluation of the efficacy of lotilaner (Credelio™) against Haemaphysalis longicornis infestations of dogs. Parasites & Vectors 11, 448 PubMed Full article.
  • Cavalleri D, Murphy M, Gorbea RL, Seewald W, Drake J, Nanchen S (2017) Laboratory evaluations of the immediate and sustained effectiveness of lotilaner (Credelio™) against three common species of ticks affecting dogs in Europe. Parasites & Vectors 10, 527 PubMed Full article.
  • Cavalleri D, Murphy M, Seewald W, Drake J, Nanchen S (2017) Two randomized, controlled studies to assess the efficacy and safety of lotilaner (Credelio™) in preventing Dermacentor reticulatus transmission of Babesia canis to dogs. Parasites & Vectors 10, 520 PubMed Full article.
  • Cavalleri D, Murphy M, Seewald W, Drake J & Nanchen S (2017) A randomised, blinded, controlled field study to assess the efficacy and safety of lotilaner tablets (Credelio™) in controlling fleas in client-owned dogs in European countries. Parasites & Vectors 10, 526 PubMed Full article.
  • Cavalleri D, Murphy M, Seewald W, Drake J & Nanchen S (2017) Assessment of the speed of flea kill of lotilaner (Credelio™) throughout the month following oral administration to dogs. Parasites & Vectors 10, 529 PubMed Full article.
  • Cavalleri D, Murphy M, Seewald W, Drake J, Nanchen S (2017) A randomized, controlled study to assess the efficacy and safety of lotilaner (Credelio™) in controlling ticks in client-owned dogs in Europe. Parasites & Vectors 10, 531 PubMed Full article.
  • Murphy M, Cavalleri D, Seewald W, Drake J, Nanchen S (2017) Laboratory evaluation of the speed of kill of lotilaner (Credelio™) against Ixodes ricinus ticks on dogs. Parasites & Vectors 10, 541 PubMed Full article.
  • Murphy M, Garcia R, Karadzovska D, Cavalleri D, Snyder D, Seewald W, Real T, Drake J, Wiseman S, Nanchen S (2017) Laboratory evaluations of the immediate and sustained efficacy of lotilaner (Credelio™) against four common species of ticks affecting dogs in North America. Parasites & Vectors 10, 523 PubMed Full article.
  • Kuntz E A & Kammanadiminti S (2017) Safety evaluation of lotilaner in dogs after oral administration as flavoured chewable tablets (Credelio™). Parasites & Vectors 10, 538 PubMed Full article.
  • Little SE (2017) Lotilaner - a novel systemic tick and flea control product for dogs. Parasites & Vectors 10, 539 PubMed Full article.
  • Rufener L, Danelli V, Bertrand D, Sager H (2017) The novel isoxazoline ectoparasiticide lotilaner (Credelio™): a non-competitive antagonist specific to invertebrates γ-aminobutyric acid-gated chloride channels (GABACls). Parasites & Vectors 10, 530 PubMed Full article.
  • Snyder DE, Wiseman S, Liebenberg J E (2017) Efficacy of lotilaner (Credelio™), a novel oral isoxazoline against naturally occurring mange mite infestations in dogs caused by Demodex spp. Parasites & Vectors 10, 532 PubMed Full article.
  • Toutain CE, Seewald W, Jung M (2017) The intravenous and oral pharmacokinetics of lotilaner in dogs. Parasites & Vectors 10, 522 PubMed Full article.
  • Karadzovska D, Chappell K, Coble S, Murphy M, Cavalleri D, Wiseman S, Drake J, Nanchen S (2017) A randomized, controlled field study to assess the efficacy and safety of lotilaner flavored chewable tablets (Credelio™) in eliminating fleas in client-owned dogs in the USA. Parasites & Vectors 10, 528 PubMed Full article.

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