Canis ISSN: 2398-2942

Lomustine

Synonym(s): CeeNU, CCNU

Contributor(s): William Brewer Jr

Introduction

Name

  • Lomustine.

Class of drug

  • Alkylating agent in the nitrosurea family.

Description

Chemical name

  • (1-(2-chloroethyl)-3-cyclohexyl-1-nitrosurea.

Molecular formula

  • C9H16C1N3O2.

Molecular weight

  • 233.71.

Physical properties

  • Yellow powder.

Storage requirements

  • Stable if stored in well closed containers at room temperature until expiration date indicated on package.
  • Avoid excessive heat over 40°C.

Uses

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Indications

Administration

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Pharmocokinetics

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed.
  • Saba C F, Thamm D H & Vail D M (2009) Combination chemotherapy with continuous L-asparaginase, lomustine, and prednisone for relapsed or refractory canine lymphoma. JVIM 23 (5), 1058-1063 PubMed.
  • Kristal O et al (2004) Hepatotoxicity associated with CCNU (lomustine) chemotherapy in dogs. JVIM 18 (1), 75-80 PubMed.

Other sources of information

  • Tennant B (2005) BSAVA Small Animal Formulary. 5th edn. Quedgeley, Gloucester, UK.

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