Canis ISSN: 2398-2942

Lokivetmab

Synonym(s): Cytopointâ„¢

Contributor(s): David Godfrey, Tim Nuttall

Introduction

Name

  • Lokivetmab.

Class of drug

  • Therapeutic caninized monoclonal antibody targeting canine interleukin 31.

Description

Chemical name

  • Lokivetmab is a caninized monoclonal antibody.

Molecular formula

  • Not reported.

Molecular weight

  • Not reported.

Physical properties

  • Ready-to-use sterile liquid in single-dose vials.

Storage requirements

  • Must be stored between 2-8C. Avoid prolonged higher temperatures, direct sunlight and freezing.

Uses

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Indications

  • Canine atopic dermatitis, particularly where:
    • Owners can't or won't give oral medication.
    • Dogs need rapid relief from pruritus.
    • Glucocorticoids Therapeutics: glucocorticoids, oclacitinib Oclacitinib and ciclosporin Ciclosporin result in adverse effects, are ineffective, and/or are contraindicated (eg young animals, infections, demodicosis Skin: demodectic mange, concurrent medication and histocytoma Skin: histocytoma and other neoplasia, etc).
    • Lokivetmab's narrow spectrum of activity means that it best suited to manage pruritus and mild inflammation in early cases of canine atopic dermatitis. Broad-spectrum anti-inflammatory agents should be considered in dogs with chronic inflammatory dermatitis and otitis.
    • Long-term use of lokivetmab should be integrated into a treatment program with skin barrier care, dietary management, allergen specific immunotherapy, and/or topical or systemic antimicrobial and anti-inflammatory treatment according to the needs of each case Therapeutics: allergy management.

Administration

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Pharmocokinetics

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Precautions

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Interactions

With other drugs

  • Caninized monoclonal antibodies should exhibit little to no interaction with systemic or topical drugs.
  • Initial studies showed no interactions with parasiticides, antibiotics, antifungals, corticosteroids, vaccines, allergen specific immunotherapy (for atopic dermatitis), antihistamines, oclacitinib Oclacitinib and ciclosporin Ciclosporin (cyclosporine).

With diagnostic tests

  • Not reported but unlikely.

Adverse Reactions

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