Canis ISSN: 2398-2942

Lithium

Introduction

Name

  • Lithium carbonate.

Class of drug

  • Anti-depressant.

Description

Physical properties

  • Tablets.

Uses

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Indications

  • Idiopathic aplastic anemia, cytotoxic-induced neutropenia or thrombocytopenia and estrogen-induced bone marrow suppressionor cyclic hematopoiesis.

Administration

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Precautions

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Interactions

with other drugs



Drugs reducing excretion of lithium (increased risk of toxicity)
  • Captopril.
  • Enalapril.
  • Loop diuretics.
  • NSAIDs.
  • Thiazides.
Diuretics
  • Lithium toxicity is made worse by sodium depletion; avoid concurrent use with diuretics.
Drugs increasing excretion of lithium
  • Sodium bicarbonate.
  • Theophylline.
Neostigmine and pyridostigmine
  • Effects antagonized by lithium.
Diltiazem or verapamil
  • Increased risk of neurotoxicity.
T3 and T4
  • The release of T3 and T4 may be blocked by lithium.

Adverse Reactions

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Further Reading

Publications

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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