Canis ISSN: 2398-2942

Liothyronine

Synonym(s): L-Tri-iodothyronine, T3, Tertroxin, Thyronine, Tri-iodothyronine

Introduction

Name

  • Liothyronine.

Class of drug

  • Hormone.

Description

Chemical name

  • O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine.
  • L-3-[4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]alanine.

Molecular formula

  • C15H12I3NO4.

Physical properties

  • Solution.
  • Tablets.

Uses

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Indications

Administration

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Precautions

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Interactions

with other drugs

  • The actions of catecholamines (epinephrine Epinephrine , norepinephrine) and sympathomimetics are enhanced by thyroxine.
  • Thyroid hormones increase the catabolism of vitamin K-dependant clotting factors, thereby potentiating the anticoagulant effects of warfarin Warfarin.
  • Diabetic patients receiving thyroid hormones may have altered insulin requirements - monitor carefully during the initiation of therapy Insulin.
  • Estrogens may increase thyroid requirements by increasing TBg Estradiol.
  • The therapeutic effect of digoxin and digitoxin may be reduced by thyroid hormones Digitoxin Digoxin.
  • Tachycardia and hypertension may develop when ketamine is given to patients receiving thyroid hormones Ketamine.

Adverse Reactions

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Further Reading

Publications

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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