Canis ISSN: 2398-2942

Lincomycin

Introduction

Name

  • Lincomycin.

Class of drug

  • Lincosamide antibiotic.

Description

Chemical name

  • (2S-trans)-methyl 6,8-dideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-D-erythro-alpha-D-galacto-octopyranoside.

Molecular formula

  • C18H34N2O6S.

Physical properties

  • Pale colored, viscous syrup.
  • Powder.
  • Colorless, sterile solution.
  • Tablets.

Storage requirements

  • <25°C.
  • In a dry environment.
  • Do not put solution in freezer.

Uses

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Indications

  • A lincosamide antibiotic that is active against gram-positive cocci (including penicillin-resistant staphylococci) and many anerobes.
  • Either bacteriostatic or bactericidal depending on the organism and drug concentration.
  • Particularly indicated for staphylococcal Staphylococcus spp bone Osteomyelitis and joint Arthritis: septic infections.
  • Clindamycin Clindamycin is more active than lincomycin, particularly against anerobes and is better absorbed from the gut.

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs



Neuromuscular blocking agents
  • May be enhanced if given with lincomycin.
Kaolin
  • The absorption of lincomycin may be reduced Kaolin.
Erythromycin
  • May prevent the binding of lincomycin to its site of action Erythromycin.

Further Reading

Publications

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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