ISSN 2398-2942      

Lincomycin

icanis
Contributor(s):

Vetstream Ltd


Introduction

Name

  • Lincomycin.

Class of drug

  • Lincosamide antibiotic.

Description

Chemical name

  • (2S-trans)-methyl 6,8-dideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-D-erythro-alpha-D-galacto-octopyranoside.

Molecular formula

  • C18H34N2O6S.

Physical properties

  • Pale colored, viscous syrup.
  • Powder.
  • Colorless, sterile solution.
  • Tablets.

Storage requirements

  • <25°C.
  • In a dry environment.
  • Do not put solution in freezer.

Uses

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Indications

  • A lincosamide antibiotic that is active against gram-positive cocci (including penicillin-resistant staphylococci) and many anerobes.
  • Either bacteriostatic or bactericidal depending on the organism and drug concentration.
  • Particularly indicated for staphylococcal Staphylococcus spp bone Osteomyelitis and joint Arthritis: septic infections.
  • Clindamycin Clindamycin is more active than lincomycin, particularly against anerobes and is better absorbed from the gut.

Administration

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Precautions

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Interactions

with other drugs

Neuromuscular blocking agents

  • May be enhanced if given with lincomycin.

Kaolin

  • The absorption of lincomycin may be reduced Kaolin.

Erythromycin

  • May prevent the binding of lincomycin to its site of action Erythromycin.

Publications

Refereed papers

Other sources of information

  • BSAVA Small Animal Formulary. Ramsey I (2017) 9th edn. Cheltenham: BSAVA.
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