Canis ISSN: 2398-2942

Lidocaine

Synonym(s): Lignocaine

Contributor(s): Sheilah Robertson

Introduction

Name

  • Lignocaine (UK).

Class of drug

  • Amide-linked local anesthetic.
  • Class 1B anti-dysrhythmic.

Description

Chemical name

  • 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide.
  • 2-diethylamino-2',6'-acetoxylidide.

Molecular formula

  • C14H22N2O.

Physical properties

  • Clear, sterile aqueous solution.

Storage requirements

  • In a cool environment (<25°C).
  • Protect from light.

Uses

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Indications

Administration

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Precautions

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Interactions

with other drugs

Cimetidine
  • May increase serum lidocaine levels or its effects if administered concurrently Cimetidine.
Propranolol
  • May increase serum lidocaine levels or its effects if administered concurrently Propranolol.
ProcainamideOther anti-dysrhythmics
  • May cause increased myocardial depression.
Acetazolamide, loop diuretics and thiazidesSuxamethonium succinylcholine
  • Large doses of lignocaine may prolong suxamethonium-induced apnea Suxamethonium.

Adverse Reactions

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Further Reading

Publications

Refereed papers

  • Recent references fromPubMed.
  • Ko J, Weil A, Maxwell L, Kitao T & Haydon T (2007)Plasma concentrations of lidocaine in dogs following lidocaine patch application.JAAHA43(5), 280-283PubMed.
  • Cassutto B H & Gfeller R W (2003)Use of intravenous lidocaine to prevent reperfusion injury and subsequent multiple organ dysfunction syndrome.J Vet Emerg Crit Care.13(3),137 - 148.

Other sources of information

  • Based on Tennant B (1999)Small Animal Formulary.3rd edn. Cheltenham: BSAVA.

ADDED