Canis ISSN: 2398-2942

Isoflurane

Contributor(s): Sheilah Robertson

Introduction

Name

  • Isoflurane.

Class of drug

  • Inhalational anaesthetic.

Description

Chemical name

  • 2-chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane.
  • 1-chloro-2,2,2-trifluoroethyl difluoromethyl ether.

Molecular formula

  • C3H2ClF5O.

Physical properties

  • Volatile halogenated ether liquid.
  • Pungent ethereal odor.
  • Non-flammable.
  • Non-explosive.

Storage requirements

  • <25°C.
  • Store away from direct heat and sunlight.
  • In original tight container.

Uses

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Indications

  • An inhalational anesthetic General anesthesia: overview.
  • Induction and maintenance of anesthesia for all types of surgery and in all species, irrespective of age.
    Rapid recovery following painful, eg orthopaedic procedures, necessitates appropriate and rapid attention to analgesia Analgesia: overview.
  • Assertations that isoflurane is safer in certain high risk cases should be discounted.
  • Potent cardiopulmonary depressant, and this depression is dose (vaporizer setting)-dependent.

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

  • Duration of non-depolarizing neuromuscular blocking agents is longer in isoflurane, compared with halothane-anesthetized animals.
  • Opioid agonists, benzodiazepines, acetylpromazine and nitrous oxide Nitrous oxide reduce the concentration of isoflurane required to achieve surgical anesthesia.

Adverse Reactions

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Further Reading

Publications

Other sources of information

  • Based on Tennant B (1999)Small Animal Formulary.3rd edn. Cheltenham: BSAVA.

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