Canis ISSN: 2398-2942

Hydrocortisone

Introduction

Name

  • Hydrocortisone.

Class of drug

  • Corticosteroid.

Description

Chemical name

  • (11-beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione.
  • Cortisol.

Molecular formula

  • C21H30O5.

Physical properties

  • Solution.
  • Powder.
  • Tablets.
  • Tastes bitter.

Uses

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Indications

  • A corticosteroid used in veterinary medicine as an anti-inflammatory drug.
  • Has only 1/4 the glucocorticoid potency of prednisolone Prednisolone and 1/30th that of dexamethasone Dexamethasone.
  • Treatment of hypoadrenocorticism Hypoadrenocorticism.
  • Treatment of shock Shock.

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs



NSAIDs
  • Increased risk of gastrointestinal ulceration if used concurrently.
Insulin
  • Glucocorticoids antagonize effects of insulin Insulin.
AnticonvulsantsAcetozolamide, amphotericin, potassium depleting diuretics
  • Increased risk of hypokalemia.

Adverse Reactions

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Further Reading

Publications

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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