Canis ISSN: 2398-2942

Griseofulvin

Contributor(s): Rosanna Marsella

Introduction

Name

  • Griseofulvin.

Class of drug

  • Antifungal agent.

Description

Chemical name

  • (1'S-trans)-7chloro-2',4,6-trimethoxy-6'-methylspiro[benzofuran-2(3H),1'[2]cyclohexene]-3,4'-dione.

Molecular formula

  • C17H17ClO6.

Physical properties

  • Tablets.
  • Insoluble in water.

Storage requirements

  • Normal conditions suitable.

Uses

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Indications

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs



Warfarin-class anticoagulants
  • Griseofulvin may decrease their activity.
Barbiturates
  • May accelerate the metabolism of griseofulvin.
  • Phenobarbitol decreases absorbtion of griseofulvin.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Aoyagi N, Ogata H, Kaniwa N et al (1982) Bioavailability of griseofulvin from tablets in beagle dogs and correlation with dissolution rate and bioavailability in humans. J Pharm Sci 71 (10), 1169-1172 PubMed.

Other sources of information

  • Based on Small Animal Formulary. Tennant Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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