ISSN 2398-2942      

Grapiprant

icanis
Contributor(s):

Gigi Davidson

Vetstream Ltd

Synonym(s): Galliprant®


Introduction

Name

  • Grapiprant.

Class of drug

  • Prostaglandin E2 EP4 receptor antagonist (piprant).
  • Non-cycloxygenase inhibiting, non-steroidal anti-inflammatory drug.

Description

Chemical name

  • N-[[[2-[4-(2-Ethyl-4,6-dimethyl-1H-imidazo[4,5-c]pyridin-1-yl)phenyl]ethyl]amino]carbonyl]-4 methylbenzenesulfonamide.

Molecular formula

  • C26H29N5O3S

Molecular weight

  • 491.61

Physical properties

  • Beige to brown, flavored tablet.

Storage requirements

  • Store at or below 86° F (30° C).

Uses

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Indications

Administration

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Precautions

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Interactions

With other drugs

  • Concurrent use with other anti-inflammatories has not been studied.
  • Concomitant use of Galliprant with other anti-inflammatory drugs, such as COX-inhibiting NSAIDs or corticosteroids, should be avoided.
  • Use with caution with other highly plasma protein bound drugs.

With diagnostic tests

  • Some dogs may develop decreased serum albumin and total protein.

Adverse Reactions

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Nagahisa A & Okumura T (2017) Pharmacology of grapiprant, a novel EP4 antagonist: receptor binding, efficacy in a rodent postoperative pain model, and a dose estimation for controlling pain in dogs. J Vet Thermacol 40 (3), 285-292 PubMed.
  • Kirkby Shaw K, Rausch-Derra L C & Rhodes L (2016) Grapiprant: an EP4 prostaglandin receptor antagonist and novel therapy for pain and inflammation. Vet Med Sci (1), 3-9 PubMed.
  • Rausch-Derra L, Rhodes L, Freshwater L et al (2016) Pharmacokinetic comparison of oral tablet and suspension formulations of grapiprant, a novel therapeutic for the pain and inflammation of osteoarthritis in dogs. J Vet Pharmcol Ther 39 (6), 566-571 PubMed.
  • Rausch-Derra L, Huebner M, Wofford J et al (2016) A prospective, randomized, masked, placebo-controlled multisite clinical study of grapiprant, an EP4 prostaglandin receptor antagonist (PRA), in dogs with osteoarthritis. J Vet Int Med 30 (3), 756-763 PubMed.
  • Rausch-Derra L, Huebner M & Rhodes L (2015) Evaluation of the safety of long-term, daily oral administration of grapiprant, a novel drug for treatment of osteoarthritis pain and inflammation, in healthy dogs. Am J Vet Res 76 (10), 853-859 PubMed.

Other sources of information

MEMBER BENEFIT

Can’t find what you’re looking for?

We have an ever growing content library on Vetlexicon so if you ever find we haven't covered something that you need please fill in the form below and let us know!

 
 
 
 

To show you are not a Bot please can you enter the number showing adjacent to this field

 Security code