Canis ISSN: 2398-2942

Glycopyrronium

Contributor(s): Sheilah Robertson

Introduction

Name

  • Glycopyrronium bromide.

Class of drug

  • Antimuscarinic agent.

Uses

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Indications

  • Used pre-operatively to decrease oral and bronchial secretions and block vagal inhibitory reflexes.
  • Its routine use for pre-anesthetic medication in dogs is controversial.
  • In conjunction with long-acting anticholinesterase drugs, eg neostigmine, pyridostigmine during antagonism of neuromuscular block.

Administration

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Precautions

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Interactions

with other drugs



Atropine, chlorpromazine, 5% dextrose, diphenhydramine, droperidol/fentanyl, lignocaine, morphine, neostigmine, pethidine, promazine, pyridostigmine, Ringers solution and 0.9% sodium chloride
  • Glycopyrronium is physically compatible.
Alkaline drugs (eg barbiturates)
  • When mixed a precipitate may form.
Antihistamines, benzodiazepines, prolonged corticosteroid use (may increase intraocular pressure), pethidine, phenothiazines, procainamide and quinidine
  • The adverse effects of antimuscarinics may be increased.
Nitrofurantoin, sympathomimetics and thiazide diuretics
  • Antimuscarinics may enhance the action.
Metoclopramide

Adverse Reactions

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Further Reading

Publications

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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